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Clinical uses of vitamin A and its derivatives, such as isotretinoin, have already been widely used with great success in the treatment of acne vulgaris in many teenagers, and dermatologists would argue that it is the Gold Standard starting point for severe acne treatment

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Specifically, icariin exhibits amphiphilic properties due to the balance between its methoxy group and glycosidic moieties, whereby the methoxy substitution (-OCH3)enhances lipophilicity while the glycosidic chains increase hydrophilicity

10.3892/etm.2019.7907 248 WuX.YangY.DouY.YeJ.BianD.WeiZ.et al (2014)

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