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417 Chemical chaperones Chemical chaperones provide a complementary strategy to alleviate ER stress

Jamalpoor A, van Gelder CA, Yousef Yengej FA, Zaal EA, Berlingerio SP, Veys KR, Pou Casellas C, Voskuil K, Essa K, Ammerlaan CM, Rega LR, van der Welle RE, Lilien MR, Rookmaaker MB, Clevers H, Klumperman J, Levtchenko E, Berkers CR, Verhaar MC, Altelaar M, Masereeuw R, Janssen MJ (2021) Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

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In the present study, we found no correlation between GSH levels and age in the ACC and OC, which may suggest different relationships between OS and aging in different brain regions

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However, multiple other cell types in the brain have also been reported to undergo ferroptosis