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Severe local depletion of arginine (arginine starvation) within this niche constitutes a fundamental mechanism of immune evasion ( Figure 3 )

However, unfavorable effects of ALDH2*2 allele have been reported in terms of the risk of some diseases such as osteoporosis [25] and neurodegenerative diseases [24, 26, 27]

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doi: 10.1038/nature05485 157 CuratCAMiranvilleASengensCDiehlMTonusCBusseRet al

It acts as a precursor to Retinol that supports cell growth