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CP influences the PI3K/AKT pathway in two distinct ways

In preclinical studies, NTZ suppresses intracellular M.tb proliferation by inhibiting the enzymatic activity of human quinone oxidoreductase (NQO1), which in turn inhibits the mTORC1 pathway and induces autophagy [19]

The cancer connection is currently theoretical but plausible given these biological effects

2016 Jun;46(6):747-9

One recent study revealed a common mechanism of action for these diverse compounds, independent of their canonical pathways: they all interfere with the cholesterol biosynthesis pathway, leading to the accumulation of 8,9-unsaturated sterols, which stimulate the differentiation of OPCs into myelinating OLGs (Hubler et al., 2018

But each of the substances would be reviewed for potential inclusions at the PCAC either during the July 2026 meeting or before February 2027