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Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification

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6.1 PD-specific features of oxidative stress 6.1.1 Dopamine oxidation and quinone stress Contemporary syntheses reinforce that dopamine auto-oxidation generates reactive o-quinones and H 2 O 2 that selectively injure substantia nigra neurons through protein modification, mitochondrial compromise, and redox cycling

doi: 10.1111/jphp.13129

S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice

To measure the forward reaction rates, we mixed RT (10 M) with equal volumes of different concentrations of GSH solutions (5, 10 and 20 mM) at pH 7.4 and monitored the formation of RT-GSH using a fluorimeter ( ex =405 nm