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Description

Astrocytic pyruvate dehydrogenase kinase-2 is involved in hypothalamic inflammation in mouse models of diabetes

Block G, Jensen CD, Norkus EP, Hudes M, Crawford PB

Glucose-6-phosphate will metabolically trifurcate into the following pathways: (i) conversion to fructose-6-phosphate by the enzyme phosphoglucose isomerase, entering the glycolytic pathway, or (ii) oxidation by glucose-6-phosphate dehydrogenase to 6-phosphogluconolactone, thereby initiating the oxidative phase of the pentose phosphate pathway

[DOI] [PMC free article] [PubMed] [Google Scholar] 27

Foci of lobular inflammation were scored as 0 (no foci), 1 ( 4 foci per 200 field)

Newer, more specific PET tracers, such as those targeting cyclooxygenase enzymes (COX-1/2), monoamine oxidase B (MAO-B), the purinergic P2X7 receptor, colony stimulating factor-1 (CSF-1), 7 nicotinic receptors and cannabinoid 2 receptors and phosphodiesterase 4B (PDE4B) should allow for more precise characterization of neuroimmune signaling [350,351,352]