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Pititto, BDA2

1986;15(4 Pt 1):57185.PubMed 18

COSTA.IT 295 trial showed that although pioglitazone had no significant difference in total cardiovascular deaths compared with sulfonylureas in primary ASCVD diabetic patients, it significantly reduced the risk of ischemic cardiovascular events by 33%

such a truncated G127X-mutant SOD1 can be discriminated from the wild-type protein because of the difference in size and also of a non-native procession of the five amino acids following Gly127 in the variant [44, 45]

Other considerations include side effects (such as nausea or digestive upset) and cost

For example, in an NAFLD mouse model, the efficacy of obeticholic acid depends on the gut microbiota