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What an elevated serum B12 represents, and why no single threshold exists A serum B12 reflects vitamin bound to transport proteins in the blood, not the amount that has reached the tissues, and the threshold for calling it high shifts with the assay, the laboratory, reference interval, and the unit on the report

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Klinische Bedeutung von Vitamin B1, B6, B12 in der Schmerztherapie

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Put plainly, the off period is not there because the compound stops working it is there because no one can point to human data showing that running it indefinitely is safe, and a scheduled break is the honest way to respect that gap

B12 B12 injections are commonly prescribed and often for many years, to fulfil 2 key functions - reverse B12 deficiency, especially if severe