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Discovery of a potent glutathione peroxidase 4 inhibitor as a selective ferroptosis inducer

PubMed , About the Author: Debbie Moon is a biologist, engineer, author, and the founder of Genetic Lifehacks where she has helped thousands of members understand how to apply genetics to their diet, lifestyle, and health decisions

While glutamate is required for regular brain activity, excess glutamate and glutathione depletion can cause brain damage

Glutathione, also known as the master antioxidant, is naturally produced by the liver and nerve cells in the human body

To test this hypothesis, we silenced NRF2, SQSTM1, PALB2 and KEAP1 in our cells

This study also demonstrated decreases in oxidative stress levels and endothelial dysfunction, exercise strength, and cognition in the intervention group