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This is often seen as a last resort since it may produce dependence on the medication among patients

Furthermore, research findings are difficult to compare and synthesize because of inconsistencies in methodology and significant differences in aspects such as dosage, method of administration, demographics, and study protocols

[Accessed 12 June 2015] Islam MM, Conigrave KM, Day CA, Nguyen Y, Haber PS

CrossRef BOND study: a randomised double-blind, placebo-controlled trial over 12 months to assess the effects of benfotiamine on morphometric, neurophysiological and clinical measures in patients with type 2 diabetes with symptomatic polyneuropathy Gidon J Bnhof, Gundega Sipola, Alexander Strom, Christian Herder, Klaus Strassburger, Birgit Knebel, Claudia Reule, Jan-Christoph Wollmann, Andrea Icks, Hadi Al-Hasani, Michael Roden, Oliver Kuss, Dan Ziegler BMJ Open.2022

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