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Directly targeting hepcidin with specific anti-hepcidin antibodies has shown promise in animal models of ACD (Sasu 2010)

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However, existing research still faces issues such as insufficient reliability in demonstrating clinical causal relationships, overreliance on animal models, and inadequate elucidation of underlying mechanisms

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Nephrol Dial Transplant (2017) 32(2):30715

How to distinguish between lethal mitochondrial damage that leads to neuronal death and potentially reversible sublethal dysfunction