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Biotin depletion exacerbated neurotoxicity in flies lacking the enzyme biotinidase, whereas biotin supplementation reversed Mn-induced pathology in wild-type flies, revealing the therapeutic potential of using biotin to treat Parkinsonism phenotypes

Best Pract Res Clin Gastroenterol 27(4):577596 Valente MJ et al (2012) Contribution of oxidative metabolism to cocaine-induced liver and kidney damage

In some embodiments, preparation of certain cations of Formulas I and IA may occur by alkylating the N-positions of the quinoline scaffold using, for example, iodomethane or methyl trifluoromethanesulfonate (see Scheme 1)

(Researcher Matthew) McMurray says cognitive changes can cause depression, anxiety or other disorders

Mild nausea or headache , particularly if the infusion is too rapid

Lately, there has been growing interest in the role of oxidative stress and redox dysregulation in epilepsy