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Proteasome inhibitors decrease the viability of pulmonary arterial smooth muscle cells by restoring mitofusin-2 expression under hypoxic conditions

Triptolide treatment significantly suppresses PD-L1 expression in oral squamous cell carcinoma and NSCLC, modulating the immune checkpoint response and effectively inhibiting tumor growth in PDTX models and an IFN- -modulated environment, while its combination with IFN- in locoregional treatment enhances antitumor immunity in triple negative breast cancer by reversing IFN- -induced PD-L1 expression and activating cytotoxic CD8 + T lymphocytes, resulting in synergistic tumor growth inhibition [982,983,984]

Levels of angiogenic cytokines prior to disease progression in metastatic colorectal cancer patients treated with bevacizumab

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