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PMID 8790365

Moreover, the significant bioenergetic and metabolic requirements of dopaminergic neurons make them especially vulnerable to mitochondrial stress

This process depends on: Vitamin B6 (P5P) as an essential enzyme cofactor Adequate availability of glycine and glutamate Sufficient cellular energy (ATP) Proper liver and mitochondrial function When this pathway is inefficient, glutathione production may be impaired even if homocysteine, B12, or folate levels appear normal