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doi: 10.1016/S1474-4422(17)30369-1 127

PD is the second most common neuro-degenerative disease in which the accumulation of aggregated -synuclein is the main factor contributing to disease progression [42, 43]

Free Radic Res 45:2936 Midaoui AE, Elimadi A, Wu L, Haddad PS, de Champlain J (2003) Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production

This association highlights the need for robust longitudinal studies and standardized oxidative stress biomarkers to clarify causality, define the timing of redox alterations, and determine the true preventive or therapeutic relevance of targeting oxidative pathways

glycine levels were 15.5% lower in plasma, an extent that is similar to what has been described in obese, insulin-resistant subjects (Newgard et al., 2009)

4,11,34 If regular monitoring is not possible, quetiapine (Seroquel) is modestly effective