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Neuroblastoma cell lines were, after ovarian cancer cell lines, the second most dependent on GPX4 (Extended Data Fig

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Certain supplements such as TUDCA or fish oil may be beneficial

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Routine testing of vitamin B12 levels in metformin-treated patients should be considered. Because metformin often causes digestive tract upset, many patients are also put on a proton pump inhibitor (PPIs) such as esomeprazole ( Nexium ), lansoprazole ( Prevacid ) or omeprazole ( Prilosec )