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In liver-related studies, Rg3 has shown hepatoprotective roles in conditions like viral hepatitis, alcoholic/non-alcoholic fatty liver disease, and fibrotic progression by suppressing inflammatory mediators, attenuating hepatic stellate cell activation, and bolstering antioxidant defenses (Wang et al., 2024)

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Experimentally, GPX4-knockout mice demonstrate that inactivation of this key ferroptosis-regulating enzyme triggers neuronal loss accompanied by lipid peroxidationa phenotype attenuated by ferroptosis inhibitors such as liproxstatin-1