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[167] [168] According to a Cochrane review on withdrawal in individuals who compulsively use amphetamine and methamphetamine, "when chronic heavy users abruptly discontinue amphetamine use, many report a time-limited withdrawal syndrome that occurs within 24 hours of their last dose." [169] This review noted that withdrawal symptoms in chronic, high-dose users are frequent, occurring in roughly 88% of cases, and persist for 34 weeks with a marked "crash" phase occurring during the first week

One limitation of this study is using an adjuvanted vaccine with an unadjuvanted control vaccine (Vanguard crLyme)

doi: 10.1007/s00726-006-0486-8

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