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doi: 10.21037/atm-21-6942 91 BezerraFSLanzettiMNesiRTNagatoACSilvaCPEKennedy-FeitosaEet al

In older adults, leaflets decrease in density, size, or both (Popov et al., 2023), reducing astrocytic interaction with synapses, limiting their homeostatic support, becoming less active in the elimination of excitatory synapses, facilitating the spillover of neurotransmitters, compromising neurotransmitter uptake and K + clearance (Popov et al., 2021), and affecting synaptic plasticity (Valtcheva and Venance, 2019