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The study aimed to determine short-term changes in feeding behavior following subcutaneous injections of vehicle or Cagrilintide at 3, 30, or 300 nmol/kg [2]

In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself

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Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome

Sato Y, Yamaguchi Y, Kawamoto T, et al