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In addition to the transgenic approach, alternative methods, such as treatments of seeds prior to sowing and/or plants with exogenous chemicals, e.g., plant growth regulators, osmoprotectants, signaling molecules etc., can also alter the glyoxalase system in plants, thereby improving stress tolerance ( Table 2 )

J Dairy Sci 2020, 103:1194511956

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Springer, The Netherlands, pp 354457 Lim YJ, Lee JS, Ku YS, Hahm KB (2009) Rescue strategies against non-steroidal anti-inflammatory drug-induced gastroduodenal damage

Further studies have confirmed that both dietary serine supplementation and genetic PHGDH overexpression effectively drive malignant progression of melanoma by elevating intracellular serine levels (87)