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These potent herbs increase the activity of antioxidant enzymes such as superoxide dismutases (SOD), catalase, glutathione peroxidase, thioredoxins and peroxiredoxins or their production, leading to decreased oxidative stress.

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On the other hand, HO-1 overexpression causes the accumulation of intracellular iron, promotes lipid peroxidation and triggers ferroptotic cell death (61,72,73)

We performed a frequentist network meta-analysis to measure network estimates for the relative outcomes