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De voorraad raakt normaliter langzaam uitgeput, mede door enterohepatische recirculatie (heropname vitamine B12 uit gal).(6) Een vitamine B12-tekort, dat kan ontstaan als de voorraad onvoldoende aangevuld wordt (onvoldoende inname of absorptie) en/of het verlies toegenomen is (oxidatieve stress, verstoorde enterohepatische recirculatie), ontwikkelt zich meestal sluipend over een periode van jaren.(7) In studies met vitamine B12 zijn vooral cyano- en hydroxocobalamine gebruikt en in mindere mate methylcobalamine en adenosylcobalamine

Taylor R, Al-Mrabeh A, Zhyzhneuskaya S et al (2018) Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for cell recovery