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Therefore, targeting different tumor antigens to overcome antigen heterogeneity and increase the CAR-T cell persistence and efficacy using the genetic modifications in CAR structure and combinatorial treatment strategies can help overcome TME hurdles [8, 9]

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Tasked with making the cast look as flawless as their figurine counterparts, Vico explained, [W]ere going to work on that glow from within. Aside from developing external treatments for the cast, featuring facials and stress-relieving therapies, Vico borrowed a simple, holistic remedy from her native Croatia milk thistle tea