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Alternatively, oxidation and activation of GCL may not require additional molecular systems, but may occur by direct interaction with glutathione to mediate redox changes that modulate activity

Clin Neuropharmacol 32(6):350352 Kamoun P, Rabier D (1987) Valproate induced inhibition of urea synthesis

Efficacy and safety of a novel combination of l-arginine glutamate and yohimbine hydrochloride: A new oral therapy for erectile dysfunction

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Both the studies showed a small but significant advantage of adding L-arginine to the treatment