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This difference in concentration is associated with the absence of catalase inside the mitochondria, what leaves GSH in charge of all inactivation of the hydrogen peroxide generated during the oxidative processes that occur in the mitochondrial matrix (57)

DOI:10.1093/ije/dyp337 [ Links ] 59

Complex III (cyt c reductase) catalyzes the transfer of electrons from the readily formed ubiquinol to cyt c in the Q cycle [126] via two distinct redox paths [127,128], while H + is pumped back into the intermembrane space [126] (Figure 2C)

Table 2 Available long-term pharmacotherapy options for CNS IDDs