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You reconstitute these with 1mL, 2mL, or sometimes 3mL of bacteriostatic water depending on desired final concentration

PMID 33206374

2 Materials and methods 2.1 Study design This study was a multi-center, prospective, double-blind, randomized clinical trial aimed to assess the absorption rate and hence bioavailibility of an innovative oral Sucrosomial B12 (Sidevit B12 developed by Pharmanutra S.p.A, Pisa, Italy) in enhancing circulatory B12 levels in healthy deficient adults, compared to various conventional oral B12 supplement formulations, selected randomly from local pharmacies at each participating center

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Dermatitis: Eczema and contact dermatitis cause the blood vessels under the skin to dilate and cause dark colorization