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[DOI] [PMC free article] [PubMed] [Google Scholar] 321.Chabosseau P., Woodier J., Cheung R., Rutter G.A

People with a heterozygous MTHFR have one normal gene and one altered gene

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10.1016/j.yexcr.2019.111592 101 HopesL.GrolezG.MoreauC.LopesR.RyckewaertG.CarrireN.et al

The CD48 protein is found in lymphocyte and other immune cells and treesThe surface of both dendritic and endothelial cells, and are involved in activation and differentiation pathways in these cells

This is not necessarily a negative side effect but rather an indication of accelerated cell turnover, where underlying congestion is brought to the surface as the skin rapidly sheds old cells and regenerates new ones