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There may be little research on the exact combination, even when both treatments are used individually in some clinical settings

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Separation of the tryptic peptides was achieved at 60 C column temperature with the following gradient of water/0.1% formic acid (solvent A) and acetonitrile/0.1% formic acid (solvent B) at a flow rate of 400 nL/min: Linear increase from 2% B to 17% B within 18 min, followed by a linear gradient to 25% B within 9 min and linear increase to 37% solvent B in additional 3 min

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& Shen, Y.-Q