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However, there is no evidence for this hypothesis

The injection is then placed in the joint or tendon, using anatomical landmarks, such as the edges of bones, to ensure that the injection is in the correct location

Given these factors, healthcare supervision is vital

Those most at risk include vegans and vegetarians, people with digestive conditions such as Crohn's disease, coeliac disease or IBS, those taking long-term metformin or proton pump inhibitors, older adults whose ability to absorb B12 through the gut declines naturally with age, those with pernicious anaemia, and anyone with a history of chronic alcohol use

Dark circles refer to the darker discoloration under the eyes that contrasts with your normal skin tone