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Oxidative Stress The concept of oxidative stress has developed from the free radical theory of oxygen toxicity developed in the 1950s with studies such as those by Rebecca Gerschman showing that oxygen poisoning and X-irradiation can both produce oxygen-derived free radicals [35,36]

It would be interesting to investigate if increased -glutamylcysteine could explain the drug resistance observed in tumours associated with -glutamyltransferase overexpression 26