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ABBREVIATIONS CBD cannabidiol CBDQ cannabidiol quinone CBN cannabinol CB1 cannabinoid receptor type 1 CB2 cannabinoid receptor type 2 CSA controlled substances act EVALI E-cigarette or vaping, product use-associated lung injury GSH glutathione HHC hexahydrocannabinol KEAP1 Kelch-like ECH-associated protein 1 Nrf2 nuclear factor erythroid 2related factor 2 HBEC primary human bronchial epithelial cell PG propylene glycol ROS reactive oxygen species THC tetrahydrocannabinol THCA tetrahydrocannabinolic acid THCB tetrahydrocannabutol THCP tetrahydrocannabiphorol THCV tetrahydrocannabivarin TOP2A topoisomerase II CDC U.S

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Interestingly, a few cases of differential metabolic changes (ie, fold change of MTX treatment over basal levels) were associated with MTX resistance (at 96 hours)