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2017), bone and cartilage protection (Lim et al

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Unlike BPC-157 and TB-500, which primarily target structural tissue repair, MOTS-c operates at the level of cellular energy metabolism: AMPK activation , MOTS-c activates AMPK (AMP-activated protein kinase), a master regulator of cellular energy homeostasis, promoting glucose uptake and fatty acid oxidation Insulin sensitivity , preclinical studies in aged and diet-induced obesity mouse models demonstrate MOTS-c improves insulin sensitivity and metabolic flexibility Exercise mimetic effects , MOTS-c levels rise in response to exercise in human studies

Bidirectional signaling between the cytoskeleton and integrins

FIGURE 2 Data collection was performed in a hierarchical manner