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Interstitial Cystitis GLX-100 is a promising mid-stage clinical candidate for IC/BPS

The erosion curve for biologics without interchangeable competitors has historically been much shallower than the small-molecule generic erosion curve (30-50% price erosion versus 70-90%), because physician inertia, formulary dynamics, and payer contracting have kept reference products competitive

The most common treatment-related unwanted events were autoimmune colitis, pneumothorax, transaminitis, seizures, hemoptysis, and hypertriglyceridemia [116]

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Indeed the activation of prodrugs in GST overexpressing cells may lead to high concentrations of an active drug, as compared to normal cells with moderate enzyme levels