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Risk scoring guides therapeutic decisions (standard therapy for low-risk, synergistic ferroptosis/cuproptosis-targeted therapy for high-risk), with dynamic optimization via periodic biomarker revalidation and panel expansion to achieve precision diagnosis and treatment

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Swedish mutant APP suppresses osteoblast differentiation and causes osteoporotic deficit, which are ameliorated by N-acetyl-L-cysteine

The presence of As in ground water, which is used for irrigation, is a matter of great concern since it affects crop productivity and contaminates food chain

To test the effect of sustained repression of lipogenic programs and a concurrent sustained induction of NRF2 activity, we monitored mice for ten weeks following the induction of Gclc deletion alone (Gclc L-KO) or in combination with Nrf2 deletion (L-DKO) in the liver (Fig