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Macropinocytosis of extracellular glutathione ameliorates tumor necrosis factor release in activated macrophages

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casei, which indicates the lack of response of the intestinal immune system to this beneficial bacterium [119]

Additionally, metal ion metabolism disturbances are the basis for the onset of various neurological diseases [175]

Mol Med Rep (2019) 19:205764

4) GPX4-independent ferroptosis suppressionDHODHCoQ10H 2 pathway in the mitochondria: Dihydroorotate dehydrogenase (DHODH), a flavin-dependent enzyme localized to the mitochondrial inner membrane, catalyzes the fourth step of pyrimidine biosynthesisconverting dihydroorotate (DHO) to orotate (OA)while transferring electrons to mitochondrial ubiquinone, reducing it to CoQ10H 2 , which acts as a radical-trapping antioxidant (107)