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17 Immune response modulation: Estrogen interacts with estrogen receptor-beta (ER-), which regulates key components of the innate immune response, such as the inflammasome

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When STING pathway is stimulated, IFNs and pro-inflammatory cytokines are produced via downstream IRF3 and NF-kB pathways to inhibit hepatitis virus replication, initiate the immune response, facilitate the oncogenesis and metastasis of HCC (122)

Ikeda T, Ishibashi H, Fujisaki R, Yamazaki M, Wakame K, Kosuna K,

Role for copper in the cellular and regulatory effects of heme-hemopexin

Methods: Plasma samples were collected from a phase 1b, open-label trial (NCT05117489) of adult pts with MASH who received MIRI 30200 mg intermittently or daily for 12 or 24 wks