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(2003) demonstrated the importance of time-specific efflux pump functionality showing that the highest levels of transcription and, therefore, efflux pump expression occurred early in biofilm development, and that this was a coordinated response of several efflux pumps causing increased levels of resistance

However, there is substantial evidence that ETAA1 requires phosphorylation for robust activation of ATR, with the individual S95D and S111D phosphomimetic mutations potentiating ATR activation by ectopically expressed ETAA1 AAD , and the double mutant acting synergistically 20

Febs Lett, 115: 253-256

R., Thorneycroft, I

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However, the dosing regimen has to be adjusted to maximize concentration of glutathione in the blood and bioavailability studies are warranted prior to designing the treatment protocol