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Nutritional status plays a role that is often underestimated

DFP, as a more conservative iron chelator with milder iron binding affinity than DFO (Cabantchik et al., 2013), is smaller and considerably more lipophilic than DFO, which allows it to cross cell membranes and penetrate into subcellular organelles, making it one of a few iron chelators that can effectively cross the BBB and access CNS iron pools (Marchand et al., 2022)

Long-term estrogen therapy without a progestogen in women with a uterus is associated with an elevated risk of endometrial neoplasia

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CDC.gov states: Aspiration before injection of vaccines or toxoids (i.e., pulling back on the syringe plunger after needle insertion but before injection) is not necessary because no large blood vessels are present at the recommended injection sites, and a process that includes aspiration might be more painful for infants (ACIP Vaccine Administration Guidelines for Immunization | Recommendations | CDC, 2018)

K., Maguire, C., Courtenay, A