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decreased appetite Mouth sores or throat soreness Tiredness or weakness Hand-foot syndrome (tender, red, or peeling skin on palms and soles) Skin dryness, rash, or itching Nail changes (brittle, darkened, or ridged nails) Hair thinning or hair loss Headache or trouble sleeping Changes in taste Eye irritation or watery eyes Back, bone, joint, or muscle pain Flushing or feeling warm Stomach pain, constipation, or cramps Weight loss Last reviewed: 2025-12-15

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J Dent Res Dent Clin Dent Prospects 11(4):265274

Optimization and Plateau Considerations (Weeks 12-16+): After 12-16 weeks of use, the rate of body composition change may slow as users approach their genetic set points or as the body adapts metabolically

Jun 2011;22(3):144-50

Dimethylfumarate efficacy and safety in palmoplantar psoriasis patient affected by hepatitis b and depression: a case report