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doi:10.1111/jdv.13690 97 Barroso, L

Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension

Eryptosis and aging Multicellular organisms are subject to the biological process of aging, and recently 12 different hallmarks of aging have been defined: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, dysregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis [415]