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This complexity suggests that altered estrogen signaling may represent a key mechanistic pathway linking NSW to BC risk and warrants further investigation considering individual circadian profiles and shift patterns

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Astrocytic gap junctional communication is reduced in amyloid--treated cultured astrocytes, but not in Alzheimers disease transgenic mice

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Additionally, certain non-gene associated reactions were included in the reconstruction based on either direct or indirect biochemical evidences from the literature

Similarly, melatonin has been demonstrated to upregulate GDNF in neural stem cells (Li et al., 2017), and in the C6 glioma cell line (Heermann et al., 2012) or their precursors (Cornejo et al., 2010)