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Their synthetic analogs, including dexamethasone, are primarily used for their potent anti-inflammatory effects in disorders of many organ systems

This limitation also applies to the PG group

Pharmaceutics 13:111 Falcone M, Meier JJ, Marini MG et al (2021) Diabetes and acute bacterial skin and skin structure infections

Another proposed mechanism involves the binding of homocysteine to the collagenous matrix of bone, which may modify collagen properties and reduce bone strength (reviewed in 113)