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To a stirred solution of 3-(3-(difluoromethoxy)phenyl)-1,5,6,7-tetrahydropyrano[3,2-c]pyrazole-6-carboxylic acid (24 mg, 0.08 mmol), HATU (32.4 mg, 0.09 mmol), and 3-amino-3-methyltetrahydrothiophene 1,1-dioxide (12.7 mg, 0.09 mmol) in DMF (387 l) was added DIPEA (40.5 l, 0.23 mmol)

[23] They have a crucial role in the prevention of many diseases, particularly coronary heart disease

Transcriptomics revealed that chemotherapy resistance in colorectal cancer liver metastasis is associated with infiltration of neutrophils and monocytes (58)

[DOI] [PubMed] [Google Scholar] 82

It has not been evaluated for safety or efficacy in humans, and no conclusions should be drawn regarding potential clinical applications

Sakthivel, P., Grunewald, J., Eklund, A., Bruder, D