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70:2935 Saeed M, Rogan E, Fernandez SV, Sheriff F, Russo J, Cavalieri E (2007) Formation of depurinating N3Adenine and N7Guanine adducts by MCF-10F cells cultured in the presence of 4-hydroxyestradiol

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Illustrative non limitative examples of ALD therapies include: an antioxidant, an antioxidant targeted to mitochondria, a histone deacetylase inhibitor, an inhibitor of mitochondria transition pore opening, an anti-inflammatory drug, a PPAR agonist, a RXR agonist, asirtuin1 agonist, a hypolipidemic drug and an autophagy activator The term "antioxidants", as used herein, refer to substances that reduce the levels of reactive oxygen species, for instance preventing the formation of such reactive oxygen species or removing them before they produce any damage

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