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342 Furthermore, exosomes can easily cross biological barriers, such as the blood-brain barrier (BBB), which has good application potential in extra-hepatic-targeted NADs delivery

In the setting of CIRS, sustained MMP-9 elevation drives endothelial permeability, immune cell infiltration, and the release of sequestered inflammatory mediators such as TNF- and IL-1, amplifying systemic immune activation

The bottom line is that the pharmacologic toolkit for modifying the microbiome is growing

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