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Accumulation of downstream metabolites, such as cholesterol and isoprenoids, serves as allosteric inhibitors of key enzymes within the pathway, thereby attenuating their activity and preventing excessive flux through the pathway

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Molecular level Brain ageing involves several critical molecular changes that collectively contribute to cognitive decline and increased susceptibility to neurodegenerative diseases

(2006) Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria: A comprehensive pro-poor health policy and strategy for the developing world