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Front Immunol 5:630 Pollizzi KN, Powell JD (2015) Regulation of T cells by mTOR: the known knowns and the known unknowns

Figure 1 In H&E staining, all the enlarged thyroid left lobes of Braf thyrV600E mice at 12 months and of Braf thyrV600E , Mieap KO/KO and Braf thyrV600E , Atg5 thyrV600E mice at 6 and 12 months comparably showed papillary growth of atypical follicular cells exhibiting hyperchromatic irregularshaped nuclei and intranuclear cytoplasmic inclusions and follicular and nestic growth of atypical follicular cells with severe nuclear atypia as we have previously detected in Braf thyrV600E mice ( Figure 1C and data not shown)

However, other investigators have reported that high glucose levels can activate NAD(P)H oxidases in vascular cells independent of mitochondrial metabolism [14]

doi: 10.1038/sj.tpj.6500369 135 LuCHYangCYLiCYHsiehCYOuHT

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Werner, C