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To induce glycation, sugars including glucose (Glc), fructose (Fru), and ribose (Rib) were employed, in addition to aldehydes such as glyoxal (GO)

In aesthetic treatments, it may be given once or twice a week initially, followed by maintenance doses at longer intervals

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Notably, the present narrative review is an extension of a previous review article that covered polyphenols and/or phytoestrogens that included daidzein, equol, genistein, and resveratrol as supplemental therapies for skin aging, which was published in Dermatology and Therapy earlier this year by Lephart (2025) [9]

Recent studies have shown that ferroptosis, a type of cell death characterized by lipid peroxidation, is a crucial factor in the pathogenesis of IIRI