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doi:10.1007/s11064-009-9981-0 Soodi M, Dashti A, Hajimehdipoor H, Akbari S, Ataei N

Similar results have been observed in studies involving the MCL and other connective tissues

Aminoglycosides, tetracyclines, and certain other antibiotics may alter gut microbiota composition, potentially affecting the small amount of vitamin B12 that is produced by colonic bacteria, though this is generally not clinically significant for patients receiving injectable B12 supplementation

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Furthermore, there is an increased risk of treatment complications for the patient

The rash responded to systemic antihistamine and local steroid therapy (55)